vinyl terminated

Physical Properties

• Appearance: Colorless, transparent, high-purity liquid
• Viscosity Range: 100–100,000 cSt (medical grade)
• Density: 0.97 g/cm³ ± 0.02 (at 25°C)
• Refractive Index: 1.403–1.406 (at 25°C)
• Surface Tension: 21.5 ± 1.5 mN/m
• Volatile Content: <0.1% (100°C × 24h)

Chemical Properties

• Biocompatibility: Compliant with full ISO 10993 testing
• Thermal Stability: Long-term stability from -50°C to 200°C
• Chemical Inertness: Resistant to physiological saline, blood, and other bodily fluids
• Sterilization Compatibility: Withstands gamma irradiation and EO (ethylene oxide) sterilization
• Purity Grade: Meets USP Class VI standards

Product Functions

• Biomaterial Modification

Significantly enhances the flexibility, elasticity, and anticoagulation properties of biomaterials.

When added to synthetic blood vessels, artificial heart valves, and other biomaterials, vinyl silicone oil helps mimic the mechanical properties of human tissues, reducing irritation and lowering thrombosis risks.

• Drug Sustained-Release Carrier Optimization

Acts as a key component in drug sustained-release systems, enabling precise control over drug release rates.

Its unique chemical structure allows specific interactions with drug molecules, ensuring prolonged and stable drug release—improving therapeutic efficacy while reducing dosing frequency.

• Medical Device Manufacturing Aid

Serves as an effective release agent in medical device production, ensuring smooth demolding and ultra-smooth surfaces to minimize tissue damage.

Plays a critical role in manufacturing soft contact lenses, catheters, and other medical products requiring high surface biocompatibility.

• Tissue Engineering Scaffold Construction

Facilitates the fabrication of 3D porous scaffolds for tissue engineering, providing an optimal microenvironment for cell adhesion, proliferation, and differentiation.

Combines excellent biocompatibility with processability to promote tissue regeneration and repair.

Applications

• Implantable Medical Devices

Applicable in products such as pacemaker casings and surface coatings for joint replacement prostheses to enhance biocompatibility and long-term stability.

• Interventional Medical Devices

Used in vascular stents and balloon catheters to improve flexibility and lubricity, reducing vascular wall damage and surgical risks.

• Drug Sustained-Release Systems

Incorporated into drug carriers like microspheres and nanoparticles to achieve precise drug release and enhance therapeutic efficacy.

• Tissue Engineering

Utilized in constructing scaffolds for skin, cartilage, and bone tissue regeneration, promoting tissue repair and regrowth.

• In Vitro Diagnostic Reagents

Enhances performance in certain immunoassay reagents, improving detection accuracy and sensitivity.

Core Advantages

Advantage	Technical Parameter	Clinical Value
Ultra-High Purity	Heavy metals <1 ppm	Ensures implant safety
Long-Term Stability	In-body durability >10 years	Reduces revision surgery risks
Drug Compatibility	Compatible with >80% drug molecules	Ideal sustained-release carrier
Processing Versatility	Precisely adjustable viscosity	Meets diverse medical device requirements
Sterilization Stability	Withstands 25kGy gamma irradiation	Guarantees sterile supply

Market Value

Core Performance Driving Market Demand

• Exceptional Biocompatibility

Passes ISO 10993 biocompatibility tests (cytotoxicity, sensitization, irritation), suitable for long-term implantation or tissue contact

Low protein adsorption reduces immune rejection (e.g., catheter coatings, artificial joint lubricants)

• Chemical and Thermal Stability

Heat-resistant (autoclavable) and oxidation-resistant, suitable for harsh medical sterilization environments (e.g., surgical instrument coatings)

Stable against acids, alkalis, and enzymes, maintaining performance in bodily fluids (e.g., in vivo sustained-release carriers)

• Tunable Mechanical Properties

Adjustable hardness and elastic modulus (0.1-10 MPa) via molecular weight and crosslinking density to match various tissue engineering needs

Low-viscosity grades (50-500 cSt) suitable for injectable fillers or minimally invasive device lubrication

• Surface Functionalization Potential

Vinyl active sites enable grafting of bioactive molecules (e.g., heparin, peptides) to enhance anticoagulation or cell adhesion

Key Market Value Drivers

• Medical Technology Advancements

Growth in minimally invasive surgery and implantable devices drives demand for high-performance medical silicone oils (e.g., endoscope lubrication, neural catheter coatings)

Increasing adoption of high-purity (metal ions <1 ppm) vinyl silicone oil in Class III medical devices

• Regulatory Compliance Advantages

Meets medical-grade certifications: USP Class VI, FDA 21 CFR 177.2600, EU MDR

Complies with GMP production requirements, suitable for sterile filling processes

• Precision and Personalized Medicine Trends

Crosslinkable properties support customized 3D-printed biological scaffolds (e.g., auricular reconstruction, cartilage repair)

Integration with drug delivery systems (e.g., silicone oil microspheres for anticancer drug loading)

• Emerging Market Growth

Rise of local medical silicone oil supply chains in Asia-Pacific (particularly China), replacing imports

Aging populations driving demand for chronic disease management products (e.g., long-term implantable sensor encapsulation materials)

Innovation Directions

• Future Technology Trends

Nano-composite enhancement: SiO₂ or carbon nanotube doping to improve mechanical properties (e.g., artificial heart valves)

Degradable vinyl silicone oils: Incorporating ester or silicate segments for controlled degradation (e.g., temporary vascular stents)

Smart responsive materials:

Temperature/pH-sensitive crosslinking (e.g., tumor-targeted drug carriers)

Light-curable silicones for instant shaping during minimally invasive surgery (e.g., endoscopic tissue adhesion)

Conclusions

• The core market value of vinyl silicone oil in medical and biomaterials lies in:

Unique combination of properties (biocompatibility + processability + stability)

Premium pricing driven by high-end medical requirements

High technical barriers with leading companies building moats through patents and certifications

• Future growth will depend on:

Precision medicine (3D printing, drug delivery systems)

Green upgrades (degradable, low-migration formulations)

Emerging market localization (import substitution in China, India supply chains)

Experimental Data & Case Studies

Experimental Data

Test Item	Test Standard	Test Result	Industry Requirement
Cytotoxicity	ISO 10993-5	Grade 0 (Non-toxic)	≤ Grade 1
Sensitization	ISO 10993-10	No sensitization reaction	No sensitization reaction
Intracutaneous Reactivity	ISO 10993-10	Score 0.3	≤ 1.0
Hemolysis Rate	ISO 10993-4	0.8%	< 5%

Successful Application Cases

• Artificial Vitreous Substitute

Clinical Need: Retinal detachment treatment

Solution: 5,000 cSt medical-grade silicone oil

Therapeutic Outcome: 92% postoperative reattachment success rate

• Drug Sustained-Release System

Technical Requirement: Stable 3-month drug release

Formulation: Silicone oil-drug composite matrix

Release Profile: Zero-order release kinetics

• Medical Catheter Coating

Clinical Issue: Tissue adhesion

Modification Method: Silicone oil surface treatment

Performance: 85% reduction in adhesion rate

Manufacturing Process, Core Technologies, and Precautions

Preparation Process

• Raw Material Refinement:

D4 monomer purification via molecular distillation (purity >99.9%)

Triple crystallization of vinyl-terminating agents

Ultra-pure water washing (conductivity <1μS/cm) for ionic impurity removal

• Polymerization System:

Continuous polymerization using three-stage series reactors

Precision temperature control (±0.5℃)

High-vacuum dehydration (residual pressure <50Pa)

• Catalyst System Optimization:

Novel immobilized platinum catalyst (loading 0.5-1.5ppm)

Bimetallic synergistic catalysis (Pt/Rh composite)

Low-temperature plasma activation pretreatment

• Post-Processing:

Molecular sieve adsorption for low-MW cyclic removal

Supercritical CO₂ extraction purification

Terminal nanofiltration (100nm pore size)

Core Technologies

• Ultra-Purification:

Deep metal ion removal (Na+<0.01ppm)

VOC control (TVOC<50ppm)

Endotoxin removal (<0.25EU/mL)

• Precision Structure Control:

Molecular weight distribution PDI<1.05

Vinyl positioning control (terminal/side group ratio)

Branching degree regulation (0-15%)

• Surface Modification:

Plasma grafting modification

Bioactive molecule immobilization

Micro-region hydrophilic/hydrophobic patterning

• Composite Enhancement:

In-situ nano-hydroxyapatite composite

Oriented carbon fiber reinforcement

Interpenetrating network construction

• Critical Process Control:

Reaction Parameters:

Temperature gradient control (80-120℃ zoning)

Shear rate optimization (50-500s⁻¹)

Oxygen content monitoring (<1ppm)

Quality Control Points:

Vinyl content deviation <±0.03%

Molecular weight variation <±3%

Batch-to-batch performance difference <2%

Precautions

• Prohibited from autoclave sterilization
• Avoid contact with strong oxidizers
• Compatibility verification required before use
• Waste disposal as medical waste

Packaging & Ordering

Packaging: 200kg/1000kg plastic drums (customizable).

Basic Product Information

• Product Name: Vinyl Terminated Fluid
• Appearance: Colorless Transparent Liquid

TYPICAL PROPERTIES

Appearance	Colorless Transparent Liquid
Viscosity (25℃),mm2/s	70-110000
Vinylcontent %	0.06-1.08
Volatile content （150℃，3h),%	≤1.5